Skip to main content

Early Intervention May Be Better for Severe Asymptomatic Aortic Stenosis

FRIDAY, May 20, 2022 -- For patients with severe asymptomatic aortic stenosis, early intervention may reduce the risk for all-cause mortality compared with conservative management, according to a systematic review and meta-analysis published online May 17 in Open Heart.

Vasiliki Tsampasian, M.D., from Norfolk and Norwich University Hospital in the United Kingdom, and colleagues conducted a systematic review and meta-analysis to examine data relating to the management of severe asymptomatic aortic stenosis. The strategies of early intervention and conservative management were compared.

The researchers found that based on a meta-analysis of data from two published randomized trials, including 302 patients, early intervention resulted in a significant reduction in all-cause mortality and in the risk for hospitalization for heart failure. No difference was seen between the groups in terms of risk for cardiovascular death. Patients treated with early intervention demonstrated improved mortality in a meta-analysis of data from eight observational studies.

"This meta-analysis shows that the data from the two recent large randomized controlled trials and previous observational studies demonstrate a favorable outcome in the group of patients treated with early intervention rather than conservative management," the authors write. "Although this may herald the beginning of a change in the management of these patients, further randomized controlled studies are needed to draw firm conclusions and identify the optimal timing of intervention."

Abstract/Full Text

© 2022 HealthDay. All rights reserved.

Read this next

Preexisting Cardiovascular Conditions Tied to Severe COVID-19 in Children

THURSDAY, May 19, 2022 -- Some previous or preexisting cardiovascular conditions are associated with increased severity of COVID-19 among children, according to a study published...

Time-Restricted Eating Reduces CVD Risk for Older Breast Cancer Survivors

THURSDAY, May 19, 2022 -- Time-restricted eating (TRE), limiting energy intake to eight hours followed by fasting for 16 hours (16:8 TRE), is associated with a reduction in...

Hispanic Patients Wait Longer When Presenting to ED With Chest Pain

MONDAY, May 16, 2022 -- Hispanic patients presenting to the emergency department with chest pain wait longer to be treated, admitted, or discharged, according to a study presented...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.